Protocols
Sermorelin protocols in the published literature
StatusFormerly FDA approved
PeptideHound Staff · Last editorially reviewed · 12 sources
This page does not publish a sermorelin protocol, and the reason is the honest answer to the question. Among the research behind this page there is no adult trial that set an amount, gave it, and reported what happened.
What exists belongs to children. The 1999 review describes two separate paediatric uses: a single intravenous dose working as a rapid and relatively specific test for the diagnosis of growth hormone deficiency, and a weight-based bedtime injection given to some prepubertal children with idiopathic growth hormone deficiency. The figures attached to those belong to that record and to nothing else.
The adult figure was never a trial parameter. A retrospective review of medical records was performed for 105 men on testosterone therapy, of whom 14 met strict inclusion criteria, and what they were prescribed was three compounds together on one thrice-daily schedule. An amount read out of clinic notes afterwards describes a clinic rather than a tested quantity, and nothing in it separates sermorelin from the two peptides beside it.
A 2026 review records the absence of regulatory approval for physique- or performance-related indications, so there is no label to quote either. Ten Class II FDA recalls of compounded sermorelin show vial strengths running from a few milligrams upward, with no two pharmacies packing the same thing. What this page does give is the arithmetic that turns a vial strength and a diluent volume into a concentration, run on numbers the reader supplies.
Evidence: Not dosing guidance · no protocol, no per-kilogram conversion and no adult equivalent published here · paediatric figures from one 1999 review · one retrospective adult chart review, three compounds at once · routes and frequency reported as study parameters
Is there a sermorelin dosage chart?
review
No, and the reason is worth more than a chart would be. Among the research behind this page there is no adult trial that set an amount, gave it, and then reported what happened.
What exists instead is three figures attached to three unrelated situations. One is a diagnostic test given to children. One is a weight-based growth schedule for children with a diagnosed deficiency. One is a prescription written at a clinic for men who were taking two other peptides at the same time.
Three figures from three settings do not make a chart. They make a list of things that happened to other people. A 2026 review of this class states the general case against publishing one, recording the absence of regulatory approval for physique- or performance-related indications alongside uncertainty surrounding product composition, dose, and stacking practices in unregulated supply chains.1
Why does this page not publish a sermorelin protocol?
review
Because every amount on record belongs to a population, a route and a purpose that no reader can step into, and turning any of them into a schedule for an adult would be an invention rather than a finding.
That is not caution for its own sake. The paediatric figures were sized for children whose own signal was missing. The adult figure was a prescription covering three compounds given together. Neither was tested in anybody resembling the person typing the search.
A 2026 review of this class sets its own peer-reviewed evidence against commonly encountered online self-administration protocols, and it is explicit about declining to lend those any weight, proposing risk communication without legitimising off-label peptide regimens.1 This page takes the same position for the same reason, and the sections below set out what the published amounts were for instead.
Which populations do the published amounts belong to?
human pilot / early trial
Two populations, and neither one is a healthy adult. The first use was diagnostic, with a single intravenous dose given to a child to see whether the pituitary answered. The 1999 review describes that as a rapid and relatively specific test for the diagnosis of growth hormone deficiency.2
The second use was therapeutic and also paediatric. A weight-based amount went in once daily at bedtime to some prepubertal children with idiopathic growth hormone deficiency, and the review is careful to call the data behind it limited.2
The third figure in circulation is adult, and it is a prescription rather than a parameter. A retrospective review of medical records was performed for 105 men on testosterone (T) therapy, and what they were given was three compounds together on one schedule.3 An amount recorded from clinic notes afterwards describes a clinic rather than a tested quantity.
Why can a per-kilogram figure not be carried across to an adult?
animal model
Because the figure was fitted to a question an adult is not asking. A weight-based amount in a child with a missing signal is sized to restart growth, and nothing among the research behind this page measured what the same arithmetic does to a grown pituitary that already works.2
There is a species problem underneath the human one. A 2016 plasma study ran its rat work and its human work separately and closed with a warning. Further studies are however required and warranted to account for potential species-related differences in metabolism and elimination of the target analytes.4 If rats and people clear a compound differently, a conversion between them is a guess wearing a decimal point.
So this page carries no conversion, no body-weight arithmetic and no adult equivalent of a paediatric figure. Each of those would be a recommendation dressed as a calculation rather than a reported finding.
What route was sermorelin given by in the studies?
review
Injection, every time, by one of two routes. The 1999 review reports that intravenous and subcutaneous sermorelin specifically stimulate growth hormone secretion from the anterior pituitary, and those are the only two routes in the human record behind this page.2
The split was by purpose rather than by preference. Intravenous was the diagnostic route, used once to provoke a response and measure it. Subcutaneous, meaning an injection into the fat just under the skin, was the route for the repeated paediatric schedule and for the adult prescription.
Animal work used the same pair. A 2003 review monitored growth hormone serum levels after intravenous (i.v.) injection in rats, and intravenous and subcutaneous (s.c.) injection in pigs.5 Knowing the route is not knowing the amount, and a route that worked in a pig is a fact about chemistry rather than a reason to think any quantity transfers.
How often was it given, and why that often?
review
Once a night in children, and three times daily in the one adult record, with the explanation sitting in the chemistry rather than in anybody's preference. Its plasma half-life is about 10-20 min in humans, so an hour after an injection there is very little circulating left to act with.5
That is why the paediatric schedule was an injection at bedtime rather than a weekly appointment. It is also why the 2017 chart review's own conclusion turns on frequency, finding that GHRP/SERM therapy increases serum IGF-1 levels with strict compliance to thrice-daily dosing in those men.3 Compliance was carrying as much of that sentence as the compound itself was.
Frequency without a quantity is not a protocol, and this page is not supplying the other half of one. What the frequency does explain is why longer-acting versions of the same releasing signal were engineered afterwards, which belongs to the comparison page rather than to this one.
Is there an oral sermorelin dose?
review
None among the research behind this page. Every administration in these sources was an injection, either into a vein or under the skin, and the animal work used the same two routes.
There is a chemical reason to expect that. Sermorelin is a short chain of amino acids, and the 2003 review's whole subject is how quickly that chain comes apart, naming enzymatic degradation at the N terminus as one of the two things that clear it within minutes.5 A digestive tract is a harsher environment for a peptide than a bloodstream is.
So the searches for an oral amount are looking for something the published record does not contain rather than something it has buried. No study among the research behind this page gave sermorelin by mouth, which means there is no figure to report and no conversion that would produce one.
Is the amount different for men and women?
human pilot / early trial
Nothing among the research behind this page separates a quantity by sex, and the adult record contains men exclusively. Compliance with therapy was assessed, and 14 men met strict inclusion criteria, out of the 105 whose records the investigators began with.3
The paediatric record does include girls, and it makes no separation between them and the boys either. Its schedule was constructed against body weight rather than against sex, in children carrying a diagnosed deficiency, which means the variable it responds to is mass rather than anything hormonal.2
So the men's version and the women's version of this question receive an identical answer. There is no established figure for either group, and the men's figure that does exist emerged from a three-compound prescription rather than from sermorelin administered on its own.
How much sermorelin do bodybuilders take?
review
Unknown, and the researchers best placed to find out have said so in print. Supraphysiological means an amount larger than a body would ever produce by itself.
A 2026 critical review reports that most published studies examine therapeutic applications under controlled dosing regimens, not the supraphysiological or combined protocols common in bodybuilding.6 That sentence is the answer in two parts. The amounts in circulation are not the amounts anybody studied, and these compounds are rarely taken alone, so even a reported figure would describe a combination rather than sermorelin.
The same review adds that beyond elite sport, the extent of peptide use in the general population is unknown, and that prevalence studies are lacking.6 A page answering this question with a number would be reporting a rumour with a decimal point in it rather than a finding.
What vial strengths show up in the recall record?
regulatory action
Ten lots, and their stated strengths vary more than anything else about them. The enforcement record holds Sermorelin 6mg/6mL Lyophilized Powder from one pharmacy and Sermorelin Injection 10mg/10mL,10mg/mL, 20mg/10mL, 9mg/9mL from another, alongside a Sermorelin Acetate 6 mg lot and a plain Sermorelin 6mg.78910
Those are packaging facts rather than quantities for anybody to administer, and they are also the numbers a person holding a vial genuinely needs. A strength describes how much dry peptide the container holds, and it says nothing whatsoever about how much of those contents anyone should withdraw.
Combination lots occupy the same register, including Sermorelin, 3 mg / GHRP-2, 3 mg / Vial.11 Across the entire enforcement record no two pharmacies were packaging an identical presentation, which is the first reason a quantity written for one vial means nothing in another.
| Lot as recorded | Stated strength |
|---|---|
| Sermorelin Lyophilized Powder | 6mg/6mL |
| Sermorelin Injection, another pharmacy | 10mg/10mL, 10mg/mL, 20mg/10mL, 9mg/9mL |
| Sermorelin Acetate | 6 mg |
| Sermorelin | 6mg |
| Sermorelin / GHRP-2 combination | 3 mg of each per vial |
How is a concentration worked out from a vial?
review
The arithmetic is short, and it runs entirely on numbers the reader supplies. Milligrams in the vial, multiplied by 1,000, divided by the millilitres of bacteriostatic water added, gives micrograms per millilitre.
Two inputs make that calculation worth anything, and both come from outside this page. The first is the vial strength, which is printed on a dispensed label and is only a statement on anything unlabelled. On unlabelled material a 2026 review records uncertainty surrounding product composition, dose, and stacking practices in unregulated supply chains.1 The second input is the volume of diluent, which is whatever the person measures out.
This page supplies no target quantity, and the reconstitution calculator does not supply one either. It converts what somebody tells it, which is the only part of this question the published record can honestly support.
Why do the published amounts differ so much?
review
Because each one was set for a different job. One was sized to provoke a single measurable response in a clinic. Another was meant to be repeated every night for a year or more. The 1999 review keeps those apart as two separate uses of one compound, calling the first a rapid and relatively specific test for the diagnosis of growth hormone deficiency and the second a course that produced significant increases in height velocity in children over twelve months.2
A second source of variation is who was being given it. A schedule written against body weight produces a different number for every child, which is the point of writing it that way and also the reason it does not travel.
The adult figure varies for a third reason: it was never a trial parameter at all. Mean duration of continuous treatment was read out of clinic notes rather than assigned in advance, which makes it an observation about one practice rather than a schedule anybody designed.3
Can you know how much is in an unlabelled vial?
primary research
Not from the outside, and that is where the arithmetic stops. Every calculation above assumes the strength printed on the vial is true, which is an assumption a pharmacy label earns and an unlabelled vial does not.
One published study went and looked. Laboratories reported human growth hormone, sermorelin, melanotan II, and no active ingredients among the seized injectables they examined, which is a finding about identity before it is a finding about quantity.12 A vial holding nothing has a concentration of zero, whatever arithmetic gets done to it.
The same study notes that such vials lack all labelling, which matters here for a narrower reason than safety.12 Without a label there is no strength to put into the sum, so the one number a reader can verify is the volume of water they measured out themselves.
What we don’t know
The gaps in the evidence matter as much as the findings.
- 01Any amount established for an adult. No adult trial among the research behind this page set a quantity in advance and then tested it.
- 02What the paediatric figure would mean in a grown body. Nothing among these sources measured a weight-based amount in an adult whose pituitary already works.
- 03How to convert between species. A 2016 plasma study closed by warning that differences in metabolism and elimination between rats and people are still unaccounted for.
- 04What sermorelin alone does at any amount. The one adult record gave it with GHRP-2 and GHRP-6 on the same schedule.
- 05Whether anything works by mouth. Every administration among the research behind this page was an injection.
- 06What amounts are actually in circulation. A 2026 review reports that prevalence studies are lacking and that published work examines controlled regimens instead.
- 07How much peptide is in an unlabelled vial. The one published analysis of seized injectables found some containing no active ingredient at all.
Sources
- 1The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration Front Endocrinol (Lausanne) 2026. doi:10.3389/fendo.2026.1822475review
- 2Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency BioDrugs 1999. doi:10.2165/00063030-199912020-00007review
- 3Growth Hormone Secretagogue Treatment in Hypogonadal Men Raises Serum Insulin-Like Growth Factor-1 Levels Am J Mens Health 2017. doi:10.1177/1557988317718662primary research
- 4Qualitative identification of growth hormone-releasing hormones in human plasma by means of immunoaffinity purification and LC-HRMS/MS Anal Bioanal Chem 2016. doi:10.1007/s00216-016-9377-3animal model
- 5PEGylation of growth hormone-releasing hormone (GRF) analogues Adv Drug Deliv Rev 2003. doi:10.1016/s0169-409x(03)00109-1review
- 6A new era of doping? Use of peptide and peptide-analog drugs in recreational and professional sport and bodybuilding: a critical review J Sports Med Phys Fitness 2026. doi:10.23736/S0022-4707.26.17773-1review
- 7Sermorelin 6mg/6mL Lyophilized Powder, Sterile Compound for Subcutaneous Injection, Diabetes Corporation of America dba DCA Pharmacy, Franklin, TN 37064-5527 sourceregulatory action
- 8Sermorelin Injection 10mg/10mL,10mg/mL, 20mg/10mL, 9mg/9mL, Rx, Western Drug Inc. 106 E. Main Street, Springerville, Arizona 85938 sourceregulatory action
- 9Sermorelin Acetate 6 mg. Compounded by Tri-Coast Pharmacy sourceregulatory action
- 10Sermorelin 6mg, Main Street Compounding Pharmacy, 126 East Main Street, Newbern, TN 38059, 888-658-6200 sourceregulatory action
- 11Sermorelin, 3 mg / GHRP-2, 3 mg / Vial, For SC Use-Lyophilized, Rx Only, KRS Global Biotechnology 791 Park of Commerce Blvd, Boca Raton, FL 33487. NDC 3321674092 sourceregulatory action
- 12Operation resistance: A snapshot of falsified antibiotics and biopharmaceutical injectables in Europe Drug Test Anal 2016. doi:10.1002/dta.1888primary research
